Prof Dame Sally Davies highlighted the rise in liver-disease deaths in the under-65s – up 20% in a decade – in her annual report.
In comparison, most of the rest of Europe has seen rates fall.
She said urgent action was needed to discourage harmful lifestyles.
She said three of the major causes of liver disease – obesity, alcohol abuse and undiagnosed hepatitis infection – were all preventable.
But despite that, premature deaths from liver disease in the under-65s had jumped by a fifth since 2000 to 10 per 100,000 people.